How It Works
Profender® Topical Solution combines emodepside and praziquantel in a highly effective treatment for roundworms, tapeworms and hookworms in cats.
How it works:
- Solution is absorbed through the skin via the hair follicles
- It enters the bloodstream
- Emodepside is transported to the intestine and kills roundworms and hookworms
- Praziquantel travels to the liver
- Praziquantel is converted to an active form in the liver
- Active praziquantel reaches the intestines and kills tapeworms
Emodepside —
Mode of Action
Emodepside stimulates latrophilin receptor at nematode neuromuscular junctions (1)
Complex signal transmission
cascade (2)
Release of inhibitory neuropeptides across the synapse (3)
Postsynaptic ion flux (4)
Paralysis and death of the parasite1,2,3,4
Praziquantel —
Mode of Action
Rapid uptake of praziquantel (1)
Calcium ion influx at cestode integumental membrane (2)
Paralysis and damaged integument (3)
Nematode digested by host (4)
In pre-approval efficacy studies, the most common side effects observed were dermal and gastrointestinal.
1 Willson J, Amliwala K, Harder A, Holden-Dye L, Walker R: (2003) The effect of the anthelmintic emodepside at the neuromuscular junction
of the parasitic nematode Ascaris suum. Parasitology, 126: 79-86.
2 Willson J, Amliwala K, Davis A, Cook A, Cuttle MF, Kriek N, Hopper NA, O’Connor V, Harder A, Walker R, Holden-Dye L: (2004) Latrotoxin receptor signaling
engages the UNC-13 dependent vesicle priming pathway in C. elegans. Current Biology, 14: 1374-1379.
3 Amliwala K, Bull K, Willson J, Harder A, Holden- Dye L, Walker R: (2004) Emodepside, a cyclooctadepsipeptide anthelmintic with a novel mode
of action. Drugs of the Future, 29: 1015- 1024.
4 Harder A, Holden-Dye L, Walker R, Wunderlich F: (2005) Mechanism of action of emodepside. Parasitol Res, 97:S1-S10.
